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Science: Previous Scientific Scholarships

 

Below details of previous scientific scholarships awarded by the ACB Scientific Committee.

2016 Round 

Below is a summary of successful applications for ACB Scientific Scholarships in 2016:
  • Elaine Cloutman-Green Application of molecular typing in a routine clinic setting for detection of cross transmission events linked to Klebsiella pneumoniae
  • Jennifer Ratner Analysis of the respiratory mycobiome in patients with asthma and cystic fibrosis
  • George Allen Investigating dynamic change in Eotaxin to differentiate Stroke from Mimic
  • Roger Bramley Investigation of the pathogenic mechanisms of Primary Hyperoxaluria Type III
  • Isabelle Piec Development of a Mass Spectrometry Immunoassay for Osteoprotogerin (OPG) antibodies

2015 Round 

Below is a summary of successful applications for ACB Scientific Scholarships in 2015:
  • Amy Dunne Development and validation of a high sensitivity oestradiol assay by tandem mass spectrometry.
  • David Taylor Serum steroid panel to improve the lateralisation of primary aldosteronism during adrenal venous sampling.
  • Elizabeth Ralph Improving outcomes in immune compromised patients: developing new diagnostic and monitoring tests for investigation of long-term immunological memory.
  • Emma Dewar Development of a LC-MS/MS Method for the Analysis of Ethanol Biomarkers in Post-Mortem Dried Blood Spots.
  • Harriet Claire Allison Antimicrobial pharmacokinetics in critically ill patients in an intensive care unit, including those receiving sustained low efficiency dialysis (SLED).
  • Joanne Morris A laboratory evaluation of a new test for measuring free light chains in blood samples.
  • Julianne Brown Gut microbiome in paediatric transplant patients.
  • Lewis Green The Development & Validation of an Automated Serum Procalcitonin immunoassay for use as a Diagnostic Marker for Bacterial sepsis and a Guide for Antimicrobial Stewardship.
  • Neil Robert Syme Development of a liquid chromatography tandem mass spectrometry method for measurement of human calcitonin in plasma.
  • Rachel Dale Substance Misuse in Pregnancy – Determining the Scale of the Problem.

Reports

The following project update reports have been received from past successful scholarship applicants:

PDF Craig McKibbin - Development of a tryptic peptide LC-MS/MS assay to quantitate IGF binding proteins and characterise changes in protein concentrations with nutritional status in the acute setting.

 

PDF Danja Schulenburg-Brand - A pilot study to identify genetic factors that may be associated with increased risk of acute neurovisceral attacks in patients with Acute Intermittent Porphyria.

 

PDF Gemma Clark - The effect of genetic variability within the hepatitis B surface antigen on quantification: an evaluation of diagnostic and clinical impact.

 

PDF Jane Armer - The performance of biochemical markers of alcohol use including carbohydrate deficient transferrin, ethyl glucuronide and ethyl sulphate to detect alcohol ingestion in clients in a community alcohol treatment programme.

 

To demonstrate the breadth and scope of studies for which we receive applications, below is a summary of the successful applications for 2009-2014.

2014


  • Victoria Miari Investigation of multi-site Neisseria gonorrhoeae infection and relationship of antimicrobial susceptibility profiles with NG-MAST.
  • Rebecca McCann Analytical assessment of a serum Calprotectin assay and its clinical utility as a screening tool for Inflammatory Bowel Disease.
  • Craig McKibbin Development of a tryptic peptide LC-MS/MS assay to quantitate IGF binding proteins and characterise changes in protein concentrations with nutritional status in the acute setting
  • Carol-Anne McInally The molecular epidemiology and clinical disease severity of infections with Human rhinoviruses in hospitalised children.
  • Andrew Chadburn Development and validation of Buhlmann faecal calprotectin ELISA kit for the measurement of serum calprotectin.
  • Christopher Parker What is the biological variation of novel markers of acute kidney injury (interleukin-18 and tissue inhibitor of metalloproteinases-2) in patients with chronic kidney disease?
  • Vaclav Stemberk Preliminary assessment of the KIM-1 lateral flow immunoassay performance as a potential POC tool for early AKI detection and disease progression monitoring.
  • Christopher Duff Development and evaluation of an App for patients with diabetes to optimise their long term monitoring.
  • Greg Toulson Evaluation of selected CSF proteins as prognostic markers of dementia in patients with Parkinson’s disease
  • Isla Wooton Quantification of Thyroglobulin in Serum Tandem Mass Spectrometry: A means to overcome Interference due to Anti-Thyroglobulin Autoantibodies?

 2013

  • Karolina Stepien, Manchester. The development of a method for the quantitation of progesterone in saliva by ultra high performance liquid chromatography tandem mass spectrometry
  • Amy Frank, Coventry. Plasma Allopregnanolone as a potential biomarker of postnatal depression in genetically vulnerable women
  • Danja Schulenburg-Brand, Cardiff. A pilot study to identify genetic factors that may be associated with increased risk of acute neurovisceral attacks in patients with Acute Intermittent Porphyria.
  • Emma Evans, Nottingham. Will a combination of renal biomarkers predict Acute Kidney Injury in critically ill patients?
  • Gary Woodward, Oxford. Evaluation of urine calprotectin as a marker of acute rejection of bladder-drained pancreas allografts
  • Jane Armer, Preston. The performance of biochemical markers of alcohol use including carbohydrate deficient transferrin, ethyl glucuronide and ethyl sulphate to detect alcohol ingestion in clients in a community alcohol treatment programme
  • Sarah Dowden, Birmingham. Development and evaluation of an LCMS/MS method for the analysis of Busulfan in plasma.
  • Gemma Clark, Nottingham. The effect of genetic variability within the hepatitis B surface antigen on quantification: an evaluation of diagnostic and clinical impact.

2012

  • Caroline Evans, Oxford Use of a functional memory B-cell ELISpot assay for the investigation of antibody responses in patients with Common Variable Immunodeficiency
  • Alexander Lawson, Birmingham Development of a method for the determination of hepcidin in serum using UPLC-MS/MS. Comparison to ESI-TOF measurements in patients with CKD, haemochromatosis and rheumatoid arthritis
  • Elaine Cloutman-Green, London Development of Adenovirus detection and typing systems to investigate the contribution of environmental contamination, cleaning and human behaviour in cross transmission
  • Dunstan Vincent, London, Laboratory evaluation of polycystic ovarian syndrome: the impact of insulin resistance and fat distribution on steroid and carbohydrate metabolism.
  • Deepa Narayanan, Hull Evaluation and implementation of biochemical markers of bone turnover in Idiopathic hypercalciuric renal stone formers
  • Lewis Couchman, London PTHrP measurement by Mass Spectrometric Immunoassay (MSIA)
  • Caroline Griffith, Leeds Iodine intake, metabolism and disposal in the first and third trimesters of pregnancy: a proof of principle study from North West England
  • Mathew Whitlock, Derby LC-MS/MS method for the determination of nitisinone (NTBC) in plasma and dried blood spots for the improved treatment monitoring of tyrosinaemia type I patients
  • Wycliffe Mbagaya, Leeds Biological variability of high sensitivity troponin in stable haemodialysis patients
  • John Shone, Dundee Investigation into the prevalence of Trichomonas vaginalis within the Scottish population: a comparison of traditional and molecular diagnostic techniques.

2011

  • Andrew Buckton, London. Pharmacogenomic dosage testing for anticoagulant therapy with clopidogrel and warfarin: an audit of clinical utility
  • Adrian Heaps, Cardiff. Investigating the impact of Filaggrin (FLG) gene mutations on the specific IgE antibody repertoire of individuals with moderate-severe atopic eczema (AE) using a protein allergen microarray.
  • Ed Hinchliffe, Manchester. Development of a method for the quantitation of tobramycin from dried blood spots by ultra high performance liquid chromatography tandem mass spectrometry
  • Satyanarayana Maddi, Salford. A systematic re-appraisal of the diagnostic utility of procalcitonin and IL-6: IL-10 ratio as rapid biomarkers of sepsis in critical illness.
  • Sarah Neale, Cardiff. Can MALDI TOF/TOF mass spectrometric analysis of serum thyroglobulin be used as a clinical assay?
  • Ceri Roberts, Oxford. Prognostic value of primary biliary cirrhosis-specific anti-nuclear antibodies in assessing response to ursodeoxycholic acid treatment.
  • Nick Unsworth, London. Development of a 4-hydroxy-2-oxoglutarate aldolase enzyme assay for the diagnosis of Primary Hyperoxaluria Type 3.

2010

  • Adrian Heaps, Cardiff. Analysis of the serum IgE repertoire in Hyper IgE Syndrome (HIES) patients using an Immuno Solid Phase Allergen Chip (ISAC)
  • Rachel Marrington, Cardiff. Development and implementation of a Capillary Electrophoresis-Tandem Mass Spectrometry (CE-MS/MS) method for measurement of HDL-C with comparison to ultracentrifugation
  • Sunita Sardiwal, Canterbury. What is the biological variation of bone-specific alkaline phosphatase in stable haemodialysis patients?
  • Angela Mallard, Truro. Comparison of detection rates and service cost for Down’s syndrome first-trimester combined screening using bloods taken at booking versus bloods taken at nuchal translucency measurement.
  • Amanda Perry, Exeter. Investigating urine C-peptide immunoassays: matrix effects, stability and standardisation.
  • Anthony Catchpole, Oxford. Can trauma-associated changes in circulating vitamin D-binding protein (Gc-globulin) affect circulating 25(OH)-vitamin D concentrations?

2009

  • James Logie, Wishaw. Analytical assessment of a kisspeptin assay and its clinical utility as a screening tool for pre-eclampsia
  • Natasha Djedovic, Harrow. Development of robust assays for the measurement of plasma renin activity and aldosterone using UPLC mass spectrometry
  • David Halsall, Cambridge. Validation of a synthetic macroprolactin complex as control material

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